Rectal cancer: the causes

Colorectal cancer is the second most common cancer in France.

Rectal cancer, more precisely, accounts for nearly 40% of new cases of colorectal cancer. There is a male predominance with a sex ratio between 1.5 and 2. The disease occurs after the quarantine, with a peak frequency between 50 and 60 years.

The causes of rectal cancer are multifactorial, both genetic and environmental.

The hereditary factor

Some hereditary conditions are associated with an increased risk of colorectal cancer. This is the case of familial adenomatous polyposis (PAF) and Lynch syndrome. In addition to these hereditary forms, it is recognized that nearly 25% of rectal cancers occur in a family context at risk without a genetic abnormality being questioned.

Environmental factors

The environmental causes of rectal cancer are now debated. The consumption of toxins (alcohol, tobacco) and food hygiene could have an influence on the appearance of a cancer of the rectum, but this one has not yet been proved. Specifically, it appears that regular consumption of tea, coffee, red meat is a factor favoring rectal cancer. And that a diet rich in fiber and fish would reduce that risk. But these assumptions are currently controversial.

Finally, prolonged intake of aspirin (or nonsteroidal anti-inflammatory drugs) reduces the risk of colorectal cancer with a benefit observed if treatment adherence has been more than ten years with doses of at least 300 mg (This treatment must imperatively be done under medical supervision, because there are risks to prolonged intake of aspirin).

Finally, another cause or more exactly factor promoting: ulcerative colitis is an inflammatory disease of the large intestine and rectum whose lesions can be cancerized.

To read :

> Colon Cancer: Aspirin Can Prevent It in Some Patients
> Gastrointestinal diseases

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