Medicinal Products

URSODESOXYCHOLIC ACID MYLAN 250 mg

Generic drug from Delursan
Therapeutic class: Gastro-Entero-Hepatology
active ingredients: Ursodeoxycholic acid
laboratory: Mylan

Coated tablet
Box of 20
All forms

Indication

Cholesterol biliary lithiasis

Pauci or asymptomatic vesicular lithiases, radiolucent, with a diameter of less than 15 mm, within a functional vesicle (evidenced by oral cholecystography), in patients with a major contraindication to surgery.

Chronic cholestatic hepatopathies

In particular, primary biliary cirrhosis, sclerosing cholangitis, hepatic cystic fibrosis.

Dosage URSODESOXYCHOLIC ACID MYLAN 250 mg Film-coated tablet Box of 20

In cholestérolic cholelithiasis:

The product is effective at the dosage of 5 to 10 mg / kg / day; however, the recommended average dosage is 7.5 mg / kg / day in a standard weight subject; in obese patients it is desirable to use 10 mg / kg / day.

It is advisable to take the treatment either one in the evening or two in the morning and evening.

The usual duration of the treatment is of the order of six months, but it can exceed a year if the calculations have a diameter greater than 1 cm.

In cholestatic liver diseases:

The optimal dosage is in the range of 13 to 15 mg / kg / day. It is recommended to gradually increase the dose in stages to obtain the optimal dosage after 4 and 8 weeks of treatment.

In cholestatic liver diseases complicating cystic fibrosis, the optimal dose is of the order of 20 mg / kg / day.

The daily dose is divided into two doses, morning and evening, at the time of meals.

Against indications

This medicine is generally not recommended during pregnancy (see section Pregnancy and breastfeeding ).

Adverse effects Ursodesoxycholic acid Mylan

Very weakly soluble in the colon, ursodeoxycholic acid has no irritating action on the colonic mucosa; cases of diarrhea are therefore very rare.

An increase in pruritus can be observed at the beginning of treatment in cases of severe cholestasis. This is why it is recommended to start treatment in such patients with a dose of 250 mg / day.

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