Medicinal Products

ACICLOVIR ZENTIVA 200 mg

Generic drug of Zovirax
Therapeutic class: Infectiology - Parasitology
active ingredients: Aciclovir
laboratory: Sanofi-Aventis France

Compressed
Box of 25
All forms

Indication

PREVENTION of Herpes Simplex Virus Infections in Immunocompromised Subjects.
IMMUNOCOMPETENT SUBJECT :
SKIN OR MUCOSAL INFECTIONS:
- Treatment of severe cutaneous or mucosal herpetic infections (usually primary infections), especially genital herpes and acute herpetic gingivostomatitis.
Because of its mode of action, aciclovir does not eradicate latent viruses. After treatment, the patient will remain exposed to the same frequency of recurrence as before.
- Treatment of recurrences of genital herpes.
- Prevention of Herpes Simplex Virus infections in subjects with at least 6 recurrences per year.
OPHTHALMOLOGICAL INFECTIONS:
- Prevention of recurrence of HSV eye infections:
. epithelial keratitis after 3 recurrences per year or in the case of known triggers,
. stromal keratitis and kerato-uveitis after 2 recurrences per year.
. in case of eye surgery.
- Treatment of keratitis and kerateuvitis with HSV.

Dosage ACICLOVIR ZENTIVA 200 mg Tablet Box of 25

Reserved for adults and children over 6 years old .
IN IMMUNODEPRIME :
Prevention of Herpes Simplex Virus Infections in Immunocompromised Subjects: 4 tablets daily, to be taken at regular intervals, throughout the immunosuppression phase during which antiherpetic prophylaxis is desired.
IMMUNOCOMPETENT SUBJECT :
SKIN OR MUCOSAL INFECTIONS:
- Treatment of severe cutaneous or mucosal herpes infections: 5 tablets daily, to be taken at regular intervals, for 5 to 10 days.
- Treatment of recurrences of genital herpes: 5 tablets per day, to be taken at regular intervals, for 5 days. Treatment should be started as soon as possible, as soon as symptoms appear.
- Prevention of Herpes Simplex Virus infections in subjects with at least 6 recurrences per year: 4 tablets per day divided into 2 doses. The treatment will be reassessed at intervals of 6 to 12 months to evaluate any possible changes related to the natural course of the disease.
OPHTHALMOLOGICAL INFECTIONS:
- Prevention of recurrence of HSV eye infections:
. epithelial keratitis after 3 recurrences per year, stromal keratitis and kerato-uveitis after 2 recurrences per year: 4 tablets at 200 mg per day divided into 2 doses. The treatment will be reassessed at intervals of 6 to 12 months to evaluate any possible changes related to the natural course of the disease.
. in case of surgery of the eye: 4 tablets at 200 mg per day, divided into 2 doses.
- Treatment of HSV eye infections:
keratitis and kerato-uveitis: 10 tablets at 200 mg daily divided into 5 doses.
IN THE INSUFFICIENT RENAL, the dosage will be adapted according to the clearance of creatinine and may be:
Clearance of creatinine: Dosage.
-> 50 ml / min: 4 tablets / day.
- 25 to 50 ml / min: Do not exceed 3 tablets / day.
- 10 to 25 ml / min: Do not exceed 2 tablets / day.
- <10 ml / min: 1 tablet / day. In case of hemodialysis, the daily dose will be administered after the session.
For the treatment of keratitis and kerato-uveitis, the dosages proposed above will be doubled.
IN THE CHILD :
In children over 6 years, the dosage is the same as in adults.

Against indications

- History of hypersensitivity to aciclovir, or to any of the other constituents of the tablet.
- Do not give to the child before 6 years, because of the risk of false route.
- Breast-feeding: In the case of a serious condition requiring general maternal treatment, breast-feeding should be avoided. In other cases, if possible, prefer the use of local treatment for which breastfeeding is possible.

Side effects Aciclovir Zentiva

- Some benign rashes regressing at discontinuation of treatment have been described.
- The following events have sometimes been reported:
. Digestive disorders: nausea, vomiting, diarrhea.
. Neuropsychic disorders: headache, lightheadedness. Neurological disorders sometimes severe and may include confusion, agitation, tremors, myoclonus, convulsions, hallucinations, psychosis, drowsiness, coma have been rarely reported: it is usually renal insufficiency having received doses higher than the recommended dosage or elderly patients (see section on warnings and precautions for use).
Complete regression is usual at stopping treatment.
The presence of these symptoms should lead to an overdose (see section on overdose).
. Hepatic disorders: Reversible increases in bilirubin and serum liver enzymes have been reported.
. Hypersensitivity and skin reactions: rash, urticaria, pruritus and exceptionally dyspnea, angioedema and anaphylactic reactions.
. Hematologic disorders: exceptional, cases of thrombocytopenia and leukopenia.
. Renal disorders: Exceptionally increased blood urea and creatinine and acute renal failure, especially in the elderly or renal failure if the dosage is exceeded.
. Various effects: cases of fatigue have sometimes been reported.

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