Medicinal Products

ACICLOVIR EVOLUGEN 200 mg

Generic drug of Zovirax
Therapeutic class: Infectiology - Parasitology
active ingredients: Aciclovir
laboratory: Evolupharm

Compressed
Box of 25
All forms

Indication

· Prevention of Herpes Simplex Virus infections in immunocompromised individuals.

· In the immunocompetent subject:
Cutaneous or mucous infections:
Treatment of severe cutaneous or mucosal herpes infections (usually primary infections), especially genital herpes and acute herpetic gingivostomatitis.
Because of its mode of action, aciclovir does not eradicate latent viruses. After treatment, the patient will remain exposed to the same frequency of recurrence as before.
Treatment of recurrences of genital herpes.
Prevention of Herpes Simplex Virus infections in subjects with at least 6 recurrences per year.
Ophthalmological infections:
Prevention of recurrence of HSV eye infections:

o epithelial keratitis after 3 recurrences per year or in case of known triggering factor,

o stromal keratitis and kerato-uveitis after 2 recurrences per year,

o in case of eye surgery.

Treatment of keratitis and kerato-uveitis with HSV.

Dosage ACICLOVIR EVOLUGEN 200 mg Tablet Box of 25

Reserved for adults and children over 6 years old.

In the immunocompromised

· Prevention of Herpes Simplex virus infections in immunocompromised subjects: 4 tablets per day, to be taken at regular intervals, throughout the immunosuppression phase during which antiherpetic prophylaxis is desired.

In the immunocompetent subject

Cutaneous or mucous infections:

· Treatment of severe cutaneous or mucosal herpetic infections: 5 tablets daily, to be taken at regular intervals, for 5 to 10 days.

· Treatment of recurrences of genital herpes: 5 tablets a day, to be taken at regular intervals, for 5 days. Treatment should be started as soon as possible, as soon as symptoms appear.

· Prevention of Herpes Simplex Virus infections in subjects with at least 6 recurrences per year: 4 tablets per day divided into 2 doses. The treatment will be reassessed at intervals of 6 to 12 months to evaluate any possible changes related to the natural course of the disease.

Ophthalmological infections:

Prevention of recurrence of HSV eye infections:

· Epithelial keratitis after 3 recurrences per year, stromal keratitis and kerato-uveitis after 2 recurrences per year: 4 tablets at 200 mg per day divided into 2 doses. The treatment will be reassessed at intervals of 6 to 12 months to evaluate any possible changes related to the natural course of the disease.

· In case of eye surgery: 4 tablets at 200 mg per day divided into 2 doses.

Treatment of HSV eye infections:

· Keratitis and kerato-uveitis: 10 tablets at 200 mg daily divided into 5 doses.

In patients with renal insufficiency, the dosage will be adapted according to the clearance of creatinine and may be:

Clearance of creatinine

Dosage

> 50 ml / min

4 tablets / day

25 to 50 ml / min

Do not exceed 3 tablets / day.

10 to 25 ml / min

Do not exceed 2 tablets / day.

<10 ml / min

1 tablet / day. In case of hemodialysis the daily dose will be administered after the session.

For the treatment of keratitis and kerato-uveitis, the dosages proposed in this table will be doubled.

In children:

In children over 6 years, the dosage is the same as in adults.

Against indications

History of hypersensitivity to aciclovir, or to any of the other constituents of the tablet.

Adverse effects Aciclovir Evolugen

Some benign rashes regressing upon discontinuation of treatment have been described.

The following events have sometimes been reported: digestive disorders, increased plasma concentrations of bilirubin or transaminases, discreet increase in uremia, headache, fatigue. These disorders have been mild and have always decreased, sometimes even despite continued treatment.

In patients with renal impairment, neurological disorders have been reported requiring discontinuation of treatment (see section Overdose ).

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