Medicinal Products

ACEBUTOLOL GNR 200 mg

Generic drug from Sectral
Therapeutic class: Cardiology and angiology
active ingredients: Acebutolol
laboratory: Sandoz

Coated tablet
Box of 30
All forms

Indication

- Hypertension.
- Prophylaxis of stress angina attacks.
- Long-term treatment after myocardial infarction (acebutolol decreases the risk of myocardial infarction recurrence and mortality, particularly sudden death).
- Treatment of certain rhythm disorders: supraventricular (tachycardias, flutters and atrial fibrillations, junctional tachycardias) or ventricular (ventricular extrasystole, ventricular tachycardias).

Dosage ACEBUTOLOL GNR 200 mg Coated Tablet Box of 30

- Hypertension:
the usual daily dose of acebutolol is 400 mg which will be administered either preferably in a single dose each morning (there is a dosage form at 400 mg) or in two doses, one in the morning and one in the evening.
This dosage may be increased in case of severe arterial hypertension.
- Prophylaxis of effort angina attacks, tachyarrhythmias:
the daily dose may vary from 400 to 800 mg (600 mg on average); starting with the lowest dose and adapting the dosage in clinical or electrocardiogram increments.
- Long-term treatment after myocardial infarction: the treatment with acebutolol should be instituted preferably between the 3rd and the 21st day after the acute episode of infarction: the dosage is 2 tablets per day, in two doses .

Against indications

CONTRAINDICATED:
- hypersensitivity to acebutolol,
- asthma and obstructive chronic bronchopneumopathies, in their severe forms,
- heart failure not controlled by treatment,
- cardiogenic shock,
- atrioventricular blocks of the second and third degrees not paired,
- Prinzmetal's angina (in pure forms and monotherapy),
- sinus disease (including sinoatrial block),
- bradycardia (<45-50 beats per minute),
- Raynaud's phenomenon and peripheral arterial disorders, in their severe forms,
- untreated pheochromocytoma,
- hypotension,
- history of anaphylactic reaction,
- breastfeeding: when treated with acebutolol, breastfeeding is contraindicated because of an important passage in the milk,
- combination with floctafenine, sultopride (see interactions).
NOT RECOMMENDED :
This drug is generally not recommended when used with amiodarone (see interactions).

Adverse effects Acebutolol Gnr

Clinically :
- The most frequently reported :
. asthenia,
. cooling of the ends,
. bradycardia, severe if any,
. digestive disorders (gastralgia, nausea, vomiting),
. incapacity.
- Much more rarely :
. slowing of atrioventricular conduction or intensification of an existing atrioventricular block,
. heart failure,
. blood pressure drop,
. bronchospasm,
. hypoglycemia,
. Raynaud's syndrome,
. worsening of existing intermittent claudication,
. various skin manifestations including psoriasiform eruptions or exacerbation of psoriasis (see precautions for use),
- Exceptionally, pneumonitis of immunoallergic origin.
Biologically :
In rare cases, it has been possible to observe the appearance of antinuclear antibodies which only exceptionally accompany clinical manifestations such as lupus syndrome and cede at the end of treatment.

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